BIOL122 Human Biological Science:Insulinsynthesis And Secretion

BIOL122 Human Biological Science

Questions:

Student Instructions:

You will have the opportunity to describe the pathophysiology and pharmacological management for a person/client suffering from diabetes mellitus (type I, type II, or gestational) or extrinsic bronchial asthma.

We expect you to show your understanding by making explicit links between pathophysiology, clinical manifestations, and pharmacological management of your person/client’s disease.

When preparing your presentation, assume that your target audience is health professionals (e.g., nurses, paramedics, midwives; all of which should have roughly the same base knowledge). Your answers to the questions below will be used to grade the ‘depth’, ‘accuracy’, and ‘clarity’ sections of your Vodcast assignment (see marking rubric provided at the end of this document).

At the beginning of your Vodcast, you need to set the scene within the first minute by introducing your patient. Following this introduction, proceed to answer the following questions. 

DIABETES MELLITUS

You must answer all questions below: 

Question 1a
Explain how both of the following are different in your patient in comparison to a healthy, non- diabetic person:

  • Insulinsynthesis and secretion; and
  • Insulinbinding to its target 

Question 1b

Explain the benefits of monitoring HbA1c in the management of your person’s/client’s disease.

Question 2a

Neuropathy and myocardial infarction are long-term consequences of poorly managed diabetes. Explain why they are more likely to occur in patients suffering from diabetes than in the non- diabetic population.

Question 2b

Both metformin and insulin may be used in the management of diabetes mellitus. By making meaningful references to your patient,

  • Choosethe one that is the most appropriate for the treatment of your patient,
  • Describethe mechanism of action of your choice, and
  • Explainwhat makes the drug you selected the most appropriate for the treatment of your 

Question 3

Define insulin resistance and explain the link between apple-type obesity and insulin resistance

Extrinsic Bronchial Asthma You must answer all questions below:

Question 1

Two of the major pathological changes that affect the airways during an asthma attack are bronchoconstriction and increased mucus production in the airways. By reflecting on the pathophysiology of bronchial asthma.

explain how these pathological changes arise in your patient. In your explanation, you are expected the outline the significance of a specific allergen that may trigger an acute asthma attack.

Question 2a

The clinical manifestations of an acute asthma attack may include the following signs and symptoms:

GROUP A

GROUP B

Cough

Airway oedema

Hypoxia

Increased respiratory rate

Wheeze

Increased heart rate

Tight chest

Dyspnoea

Choose one clinical manifestation from GROUP A and one from GROUP B and relate them to the underlying pathophysiology for your person. In your answer, explain the link between an acute asthma attack and both signs/symptoms you chose.

Question 2b

Salbutamol and corticosteroids are used in the management of asthma. Explain the mechanism of action of these two medications and their benefits in managing your patient’s condition.

Question 3

Adequate education of patients suffering from/prone to asthma attacks is important in asthma management. Briefly summarize the advice you would give to your patient in respect to

  • Corticosteroidadministration and
  • Strategies relating to effective prevention and management of their acute asthmatic

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